Key points are not available for this paper at this time.
The sequencing of the human genome has revealed an almost complete “parts list” for the study of the genetic basis of disease.1,2 The Online Mendelian Inheritance in Man data base lists more than 1000 human genes that have been implicated in specific diseases.3 It is likely that within a few years the causative lesion in most diseases that result from a mutation in a single gene will have been characterized, and geneticists are using sophisticated methods to track genes in polygenic diseases — that is, diseases caused by defects in more than a single gene.Often, however, the rapid . . .
Hariharan et al. (Wed,) studied this question.