Treatment of Migraine With Histamine

Histamine has been reported to have a prophylactic and a curative effect on migraine.1This drug has been used in the treatment of migraine at the Mayo Clinic since 1937. We are reporting the results of treatment in an attempt to evaluate histamine therapy in the clinical management of migraine. CRITERIA The majority of physicians who have carefully observed the syndrome of migraine agree that five factors are fundamental to that syndrome. These factors are: (1) periodicity, (2) cephalalgia, (3) gastrointestinal dysfunction, (4) cortical disturbance and (5) a familial history of migraine. It is generally recognized that all five factors are not necessarily present in any 1 case at all times, although many physicians would not hesitate to classify as migraine certain conditions in which all five factors never have been present. For this study, only those cases were selected in which both periodicity and cephalalgia were present in adcition