Key points are not available for this paper at this time.
In previous communications I1reported that thepHof nasal secretions in situ in clinically normal nasal passages ranges from approximately 5.5 to 6.5 and that these secretions become alkaline during acute rhinitis and acute rhinosinusitis and during the more active phases of allergic rhinitis. In the light of Meyer's2recent accomplishment—increasing the activity of lysozyme from eight to two hundred and fifty times by the addition of a minute amount of biotin—the relationship of thepHof nasal secretions in situ to the activity of lysozyme is of interest. Lysozyme was first described in 1922 by Dr. Alexander Fleming, discoverer of penicillin. It is a substance found in various body tissues and secretions—among them, nasal secretions—which has the property of dissolving certain bacteria. Though lysozyme is most active against nonpathogenic organisms, it can attack pathogenic organisms when allowed to act in the full strength in which it occurs in
N. D. FABRICANT (Mon,) studied this question.