The composite VE/VCO2 slope/pVO2 ratio was a less effective predictor of mortality than pVO2 alone in patients with chronic heart failure (48 deaths among 212 analyzed patients over a median 42 months).
Cohort (n=388)
BACKGROUND: A low peak oxygen uptake (pVO(2)) and steep VE/VCO(2) slope are independently associated with a worse prognosis in patients with chronic heart failure (CHF). We wished to confirm whether combining these variables as a ratio would lead to a more accurate predictor of prognosis than using either alone. METHODS: 388 CHF patients completed a treadmill-based cardiopulmonary exercise test (CPET) to volitional exhaustion using a modified Bruce protocol. RESULTS: 212 CHF patients completed the CPET with a peak RER >or= 1.0. Of these, 48 patients died and one was transplanted during follow-up. In surviving patients, the median follow-up period was 42 months (IQR 34-49 months). The ratio VE/VCO(2) slope/pVO(2) was calculated for each individual and its ability to predict outcome compared with other variables. The Cox multivariable survival analysis showed that pVO(2) was the strongest independent predictor of mortality in CHF patients. CONCLUSION: Our study shows that the composite variable VE/VCO(2) slope/pVO(2) is a less effective prognosticator than pVO(2) alone in patients with CHF.
Ingle et al. (Tue,) conducted a cohort in Chronic heart failure (n=388). VE/VCO2 slope/pVO2 ratio vs. pVO2 alone was evaluated on Mortality. The composite VE/VCO2 slope/pVO2 ratio was a less effective predictor of mortality than pVO2 alone in patients with chronic heart failure (48 deaths among 212 analyzed patients over a median 42 months).