Primary prevention with anticoagulants and aspirin in Swedish atrial fibrillation patients could save Kr175 million annually, provided the risk of serious hemorrhagic complications is kept low.
Is primary prevention with anticoagulants or aspirin cost-effective for stroke prevention in patients with atrial fibrillation?
Primary prevention of stroke with anticoagulants or aspirin in atrial fibrillation is cost-effective in Sweden, provided the risk of serious hemorrhage is kept low.
OBJECTIVE: To assess the potential effects of primary prevention with anticoagulants or aspirin in atrial fibrillation on Swedish population. DESIGN: Analysis of cost effectiveness based on the following assumptions: about 83,000 people have atrial fibrillation in Sweden, of whom 22,000 would be potential candidates for treatment with anticoagulants and 55,000 for aspirin treatment; the annual 5% stroke rate is reduced by 64% (with anticoagulants) and 25% (with aspirin); incidence of intracranial haemorrhage of 0.3%, 1.3%, or 2.0% per year; direct and indirect costs of a stroke of Kr180,000 and Kr90,000; estimated annual cost of treatment is Kr5030 for anticoagulants and Kr100 for aspirin. SETTING: Total Swedish population. MAIN OUTCOME MEASURES: Direct and indirect costs of stroke saved, number of strokes prevented, and cost of preventive treatment. RESULTS: Depending on the rate of haemorrhagic complications 34 to 83 patients would need to be treated annually with anticoagulants to prevent one stroke; 83 patients would need to be treated with aspirin. Giving anticoagulant treatment only would reduce costs by Kr60 million if the incidence of intracranial haemorrhage were 0.3% but would imply a net expense if the complication rate exceeded 1.3%. The total savings from giving anticoagulant (22,000 patients) and aspirin (55,000 patients) treatment would be Kr175 million per year corresponding to 2 million pounds per million inhabitants each year. CONCLUSIONS: Treatment with anticoagulants and, if contraindications exist, with aspirin is cost effective provided that the risk of serious haemorrhage complications due to anticoagulants is kept low.
Gustafsson et al. (Sat,) conducted a other in Atrial fibrillation (n=83,000). Anticoagulants and aspirin vs. No treatment (implied) was evaluated on Direct and indirect costs of stroke saved, number of strokes prevented, and cost of preventive treatment. Primary prevention with anticoagulants and aspirin in Swedish atrial fibrillation patients could save Kr175 million annually, provided the risk of serious hemorrhagic complications is kept low.