Total coronary blood flow was significantly lower in patients with coronary heart disease (288 ml/min) and noncoronary heart disease (292 ml/min) compared to normal subjects (386 ml/min).
Cross-Sectional (n=54)
No
Does total and effective coronary blood flow differ between normal subjects, patients with coronary heart disease, and patients with noncoronary heart disease?
Total and effective coronary blood flow are significantly reduced in patients with coronary and noncoronary heart disease compared to normal subjects, with a significant discrepancy between total and effective flow in diseased states.
Absolute Event Rate: 288% vs 386%
p-value: p=<0.05
There are no data available concerning total coronary blood flow to the whole heart (CBF) in man. "Effective" or "nutrient" coronary blood flow to the whole heart (MBF), supposedly a measure of flow through exchanging channels of the coronary circulation, has been measured but its validity has not been established. Accordingly, CBF and MBF were measured in 9 normal subjects, 26 patients with coronary heart disease (CHD), and 19 with noncoronary, mostly valvular heart disease (NCHD), by coincidence counting 84Rb technique. Two methods were used: single bolus (24 cases) and continuous infusion (30 cases). Various other parameters including myocardial oxygen utilization (MVO2) and lactate extraction ratio were determined. In the normal subjects CBF (386 +/- 77 ml/min) was significantly higher (P 0.3), whereas the differences were significant in CHD (P < 0.01) and NCHD (P < 0.02). This was merely a reflection of a reduced ratio of myocardial to total body epsilon Rb in CHD and NCHD, and available evidence indicates that this may be an expression of depressed transport of Rb+ rather than true shunting.
Mymin et al. (Fri,) conducted a cross-sectional in Coronary and noncoronary heart disease (n=54). Coronary heart disease and noncoronary heart disease vs. Normal subjects was evaluated on Total coronary blood flow (CBF) (p=<0.05). Total coronary blood flow was significantly lower in patients with coronary heart disease (288 ml/min) and noncoronary heart disease (292 ml/min) compared to normal subjects (386 ml/min).