Magnetic resonance tissue phase mapping demonstrated that increased age reduces diastolic long-axis velocities (P<0.003), and women have reduced systolic twist compared to men (P=0.009).
Observational (n=58)
BACKGROUND: An exact understanding of normal age- and gender-matched regional myocardial performance is an essential prerequisite for the diagnosis of heart disease. Magnetic resonance phase-contrast imaging (tissue phase mapping) enabling the analysis of segmental, 3-directional myocardial velocities with high temporal resolution (13. 8 ms) was used to assess left ventricular motion. METHODS AND RESULTS: Radial, long-axis, and rotational myocardial velocities were acquired in 58 healthy volunteers (3 age groups, 29 women) in left ventricular basal, midventricular, and apical short-axis locations. For increased age, reduced (P<0. 003) and prolonged long-axis and radial velocities (P<0. 05) during diastole and reduced long-axis velocities (P<0. 001) and apical rotation (P<0. 005) during systole were found for both genders. Women demonstrated a reduced systolic twist (P=0. 009), apical rotation (P=0. 01), and systolic radial velocities (P<0. 02) compared with men. Segmental analysis of long-axis motion with aging revealed differences in regional reduction of systolic (lateral 52% versus 30%) and diastolic (lateral 57% versus 41%) velocities in women compared with men. In basal segments, young women demonstrated higher long-axis velocities (+11% during diastole) than men, whereas this difference was reversed in older subjects (same segments, -20%). In addition, increased age resulted in a prolonged time to peak diastolic apical rotation (P<0. 04) in women compared with men. CONCLUSIONS: Age and gender strongly influence regional myocardial motion. Tissue phase mapping provides a comprehensive quantitative analysis of all myocardial velocities with high temporal and spatial resolution. The knowledge of the detected age- and gender-related differences in myocardial motion is fundamental for further investigations of cardiac disease. Clinical Trial Registration- http: //www. zks. uni-freiburg. de/uklreg/php/suchergebnisₐll. php. Identifier: UKF001739.
Föll et al. (Wed,) conducted a observational in Healthy volunteers (n=58). Magnetic resonance phase-contrast imaging (tissue phase mapping) vs. Age and gender groups was evaluated on Radial, long-axis, and rotational myocardial velocities. Magnetic resonance tissue phase mapping demonstrated that increased age reduces diastolic long-axis velocities (P<0.003), and women have reduced systolic twist compared to men (P=0.009).