LPS-induced increase in CTRP1 gene expression in adipose tissues of Sprague-Dawley rats is mediated by TNF-alpha and IL-1beta, suggesting an association with low-grade chronic inflammation.
CTRP1 expression is upregulated by inflammatory cytokines and in diabetic models, suggesting an association with low-grade chronic inflammation in adipose tissue.
CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-alpha and IL-1beta. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (fa/fa) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.
Kim et al. (Wed,) conducted a other in Low-grade chronic inflammation in adipose tissues. LPS stimulation vs. Absence of LPS stimulation was evaluated on CTRP1 gene expression. LPS-induced increase in CTRP1 gene expression in adipose tissues of Sprague-Dawley rats is mediated by TNF-alpha and IL-1beta, suggesting an association with low-grade chronic inflammation.