Infusion of nonesterified fatty acids in healthy adults decreased arterial and renal venous plasma norepinephrine levels by 15% and 20%, respectively (P < .05 for both).
Does infusion of fat emulsion and heparin alter systemic and renal norepinephrine kinetics in healthy adults?
Increasing circulating nonesterified fatty acids does not stimulate whole-body or renal sympathetic activity in healthy adults, but rather decreases arterial and renal venous plasma norepinephrine levels.
Tasa de eventos absoluta: 10% vs 11.6%
valor p: p=0.067
BACKGROUND: Sympathetic activity and renal norepinephrine spillover are increased in obese individuals. We have reported that infusion of nonesterified fatty acids increases blood pressure in animals through stimulation of the sympathetic nervous system. METHODS: In this study, we assessed the effect of increasing circulating nonesterified fatty acids on systemic and renal norepinephrine kinetics in healthy adults by infusing fat emulsion and heparin for 4 h. (3)H-norepinephrine was infused for 60 min before and again during the last hour of the fatty acid infusion to assess norepinephrine kinetics. Renal venous blood samples were obtained to calculate renal norepinephrine spillover. RESULTS: Nonesterified fatty acid levels increased threefold during the first hour and remained elevated throughout the study. Arterial and renal venous plasma norepinephrine levels fell by 15% and 20%, respectively, during the infusion (P < .05 for both). Kinetic analysis indicated that systemic release of norepinephrine into an extravascular compartment decreased from 11.6 +/- 1.1 to 10.0 +/- 1.3 nmol/min/m(2) (P = .067) and renal venous norepinephrine spillover decreased from 454 +/- 54 pmol/min (P = .055). CONCLUSIONS: These results indicate that nonesterified fatty acids do not have a direct stimulating effect on whole-body or renal sympathetic activity. It is possible that increased plasma levels of fatty acids serve as a signal to decrease sympathetic tone during the fasting state.
Grekin et al. (Tue,) conducted a other in Healthy. Fat emulsion and heparin infusion vs. Baseline (pre-infusion) was evaluated on Systemic release of norepinephrine into an extravascular compartment (nmol/min/m2) (p=0.067). Infusion of nonesterified fatty acids in healthy adults decreased arterial and renal venous plasma norepinephrine levels by 15% and 20%, respectively (P < .05 for both).