April 23, 2014
View Full PaperCT Angiographic Evaluation of Genetic Vascular Disease: Role in Detection, Staging, and Management of Complex Vascular Pathologic Conditions
Key Result
CT angiographic evaluation of genetic vascular diseases enables radiologists to identify discriminating clinical and imaging features to aid in correct diagnosis.
Structured PICO
What is the role of CT angiographic evaluation in the detection, staging, and management of complex vascular pathologic conditions in patients with genetic vascular diseases?
P
Population
Patients with connective tissue diseases, specifically Marfan syndrome, Loeys-Dietz syndrome, and vascular Ehlers-Danlos syndrome
I
Intervention
CT Angiographic Evaluation
O
Outcome
Detection, staging, and management of complex vascular pathologic conditions
CT angiography provides discriminating imaging features that aid in the correct diagnosis and management of cardiovascular involvement in genetic connective tissue diseases.
Abstract
OBJECTIVE: Arterial dissection and aneurysm rupture are significant sources of morbidity and mortality in patients with connective tissue diseases. This article provides a detailed analysis of cardiovascular involvement in Marfan syndrome, Loeys-Dietz syndrome, and vascular Ehlers-Danlos syndrome. CONCLUSION: Although these syndromes share some overlapping features, they have discriminating clinical and imaging features, and knowledge of these features enables the radiologist to aid the referring clinician in making the correct diagnosis.