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We have tested the effect of leukotriene C4 (LTC4, 6 X 10(-8) to 6 X 10(-5) M) on the output of radiolabelled mucins from the trachea of the anaesthetized cat. Doses between 6 X 10(-7) M and 6 X 10(-5) M stimulated mucin release. FPL 55712 (9.5 X 10(-6) M) partially antagonized the effect of the highest dose of LTC4. Tests of LTC4 (6 X 10(-8) to 6 X 10(-6) M) on cat trachea in vitro failed to show any effect on mucin secretion. We conclude that leukotrienes may be one of the mediators of mucus secretion into the inflamed airway.
Peatfield et al. (Mon,) studied this question.
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