Intracoronary Thrombolysis in Evolving Myocardial Infarction

Editorials1 October 1981Intracoronary Thrombolysis in Evolving Myocardial InfarctionWILLIAM GANZ, M.D.WILLIAM GANZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-4-500 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExtensive myocardial necrosis remains the principal cause of death and morbidity among patients hospitalized with acute myocardial infarction. The clinical impact of interventions designed to reduce necrosis by reducing myocardial oxygen demand, augmenting collateral blood supply, or correcting ischemic cellular defects has been disappointing. As a result, the conviction that restoring blood flow to the ischemic myocardium is needed for clinically significant reduction of necrosis is becoming stronger.The rate of myocardial necrosis is known to differ widely in experimental animals, from virtually no necrosis after several hours of coronary artery occlusion to transmural necrosis after only 40 minutes of...References1. BELLER G, HOOD W, and SMITH T. Effects of ischemia and coronary reperfusion on regional myocardial blood flow and on the epicardial electrocardiogram. Cardiovasc Res. 1977;2:489-98. CrossrefGoogle Scholar2. IRVIN R, COBB F, and ROE C. Acute myocardial infarction and MB creatine phosphokinase. Relationship between onset of symptoms of infarction and appearance and disappearance of enzyme. Arch Intern Med. 1980;140:329-34. CrossrefMedlineGoogle Scholar3. REIMER K, LOWE J, RASMUSSEN M, and JENNINGS R. The wavefront phenomenon of ischemic cell death. 1. 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Author, Article, and Disclosure InformationAuthors: WILLIAM GANZ, M.D.Affiliations: Division of Cardiology Cedars-Sinai Medical Center University of California School of Medicine Los Angeles; Los Angeles, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReperfusion therapy of acute myocardial infarctionInterventional Therapy for the Treatment of Acute Myocardial Infarction: Thrombolysis with and without AngioplastySuccessful result from delayed streptokinase administration: Subtotal thrombotic occlusion in a subsequently normal coronary arteryPercutaneous transluminal coronary angioplasty: Application for acute myocardial infarctionPercutaneous transluminal coronary angioplasty with and without thrombolytic therapy for treatment of acute myocardial infarctionSecondary Prevention of Coronary Heart DiseaseCorrection: Editorial on Intracoronary Thrombolysis in Infarction 1 October 1981Volume 95, Issue 4Page: 500-502KeywordsAcute myocardial infarctionBloodBlood flowCoronary arteriesMorbidityMyocardial infarctionMyocardiumNecrosisOxygen ePublished: 1 December 2008 Issue Published: 1 October 1981 PDF downloadLoading ...