Chemistry and Biological Activity of Rocaglamide Derivatives and Related Compounds in Aglaia Species (Meliaceae)

The genus Aglaia is the source of a unique group of natural products featuring a cyclopentabtetrahydrobenzofuran skeleton. Commonly these compounds, which until now include more than 50 naturally occurring derivatives, are named after the parent compound, rocaglamide, which was described for the first time almost twenty years ago. This review highlights the chemical diversity of rocaglamide derivatives and of biogenetically similar compounds from the genus Aglaia and their remarkable biological activity in the fields of insecticides and cytostatic agents. With a few exceptions, all naturally occurring rocaglamide derivatives exhibit striking insecticidal activity against various pest insects. In addition, they display pronounced cytostatic activity against human cancer cell lines in vitro. Furthermore, it was shown recently that rocaglamide and several of its congeners inhibit NF-kB induced gene activation in human T cells and are able to elicit apoptosis in resistant tumor cells. Taken together, these data make rocaglamide derivatives interesting candidates for possible therapeutic agents primarily in the field of cancer chemotherapy. In some Aglaia species, rocaglamide derivatives co-occur with biogenetically similar natural products of the aglain, aglaforbesin or forbaglin type. These latter compounds differ from rocaglamide and its congeners mainly by the nature of their heterocycle. Furthermore, they seem to be devoid of significant biological activity at least in the areas mentioned above, thereby pointing to the cyclopentabtetrahydrobenzofuran core of the rocaglamide skeleton as one essential structural requirement for the pronounced biological activity of the rocaglamides. Keywords: Rocaglamide Derivatives, rocaglaol, aglain Derivatives, Aglaforbesin Derivatives, Forbagline Derivatives, Insecticidal Activity, Antiproliferative Activity