Mean platelet volume is a universally available and attractive clinical marker for evaluating platelet hyperreactivity in patients with diabetes mellitus.
Mean platelet volume (MPV) serves as an accessible clinical marker for evaluating platelet hyperreactivity, which plays a crucial role in atherothrombotic complications in diabetes.
Atherothrombotic complications are important causes of morbidity and mortality in diabetic patients. Diabetes has been considered to be a prothrombotic status. Several factors contribute to the prothrombotic condition, such as increasing coagulation, impaired fibrinolysis, endothelial dysfunction, and platelet hyperreactivity. Among the factors that contribute to the prothrombotic status in diabetes, altered platelet function plays a crucial role. Although understanding platelet function abnormalities in diabetes still remains as a challenge, more attention should be focused on platelet function for effective management and the prediction of atherothrombotic events in diabetic patients. This review will provide an overview on the current status of knowledge of platelet function abnormalities and clinical marker of platelet hyperreactivity in patients with diabetes.
Kim et al. (2013) conducted a review in Diabetes Mellitus. Mean platelet volume is a universally available and attractive clinical marker for evaluating platelet hyperreactivity in patients with diabetes mellitus.