Adrenal specific renin levels in spontaneously hypertensive rats were 6-8 times higher than in normotensive controls, even before the development of hypertension at 3 weeks of age.
Effect estimate: 6-8 times as high
The specific renin (EC 3.4.99.19) activity in the adrenal of spontaneously hypertensive rats was determined by a method that is capable of distinguishing renin from nonspecific renin-like activity of proteases by using specific antibody to renin. The renin level in the adrenals of adult spontaneously hypertensive rats with established hypertension was found to be 6-8 times as high as that of the normotensive control Wistar-Kyoto strain. The large difference in the adrenal renin level was observed even in 3-wk-old rats in which hypertension has not yet developed. The adrenal renin level was increased by bilateral nephrectomy in both the hypertensive and normotensive strains. A larger quantity of renin was found in the adrenal cortex than in the medulla, and the difference between the hypertensive strain and the normotensive strain was more prominent in the cortex than in the medulla. These results suggest possible involvement of adrenal renin in the development and in the early maintenance phase of hypertension in this animal mode of human essential hypertension by affecting the adrenocortical or adrenomedullary activity, or both.
Naruse et al. (Sat,) conducted a other in Hypertension (animal model). Spontaneously hypertensive strain vs. Normotensive Wistar-Kyoto strain was evaluated on Adrenal specific renin activity (6-8 times as high). Adrenal specific renin levels in spontaneously hypertensive rats were 6-8 times higher than in normotensive controls, even before the development of hypertension at 3 weeks of age.