A multidisciplinary disease management program was dominant in moderately frail heart failure patients, with mean savings of 2635.42 euros for frailty score 3 (95% CI 352.60-4917.00; P=0.025).
RCT (n=173)
randomized
No
Effect estimate: Mean savings 2635.42 euro (95% CI 352.60-4917.00)
p-value: p=0.025
BACKGROUND: Disease management programs (DMP) improve outcomes in patients with heart failure. Because older heart failure patients represent a heterogeneous population, the aim of this study was to determine which patients benefit mostly from a DMP, by means of their frailty profile. SETTING: Heart failure outpatient clinic. METHODS: Consecutive (n = 173) patients aged more than 70 years were randomized to a multidisciplinary DMP (n = 86) or usual care (n = 87). A modified frailty score (range 1-6) was used as an index of global functional impairment. RESULTS: Mild to moderate frailty (frailty score = 2-3) was associated with significant improvements in outcomes (death and/or heart failure admission, heart failure admissions and all-cause admissions) in DMP patients vs. usual care. Even in more frail patients (frailty score = 4-6) a significant reduction in heart failure admissions was observed. By contrast, nonfrail patients (frailty score = 1) did not derive significant benefit. In the cost-effectiveness analysis, the mean savings per patient, stratified according to their frailty score, were -1003.31 euro for frailty score 1 (95% confidence interval -3717.00-1709.00), 1104.72 euro for frailty score 2 (-280.6-2491.00), 2635.42 euro for frailty score 3 (352.60-4917.00, P = 0.025) and 419.53 euro for frailty score 4-6 (-1909.00-2749.00). Intervention was therefore significantly cost saving in moderately frail, but not in nonfrail or severely frail patients. Thus, DMP was dominant (i.e. both less costly and more effective than usual care) in moderately frail patients. At sensitivity analysis, DMP remained dominant even to changes in cost of intervention and hospitalizations. CONCLUSION: This suggests that an intensive, hospital-based DMP appears to be more effective in older patients with mild-to-moderate levels of frailty. Thus, a multidimensional assessment of frailty seems to be a useful tool for appropriate selection of model of care.
Pulignano et al. (Wed,) conducted a rct in heart failure (n=173). multidisciplinary disease management program vs. usual care was evaluated on mean savings per patient (frailty score 3) (Mean savings 2635.42 euro, 95% CI 352.60-4917.00, p=0.025). A multidisciplinary disease management program was dominant in moderately frail heart failure patients, with mean savings of 2635.42 euros for frailty score 3 (95% CI 352.60-4917.00; P=0.025).
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