Do PDE5 inhibitors improve RV inotropy and decrease RV afterload in hypertrophied human right ventricles?
PDE5 inhibitors improve right ventricular contractility and reduce afterload without systemic effects, supporting their use in right ventricular diseases like pulmonary arterial hypertension.
The ability of PDE5 inhibitors to increase RV inotropy and to decrease RV afterload without significantly affecting systemic hemodynamics makes them ideal for the treatment of diseases affecting the RV, including pulmonary arterial hypertension.
Nagendran et al. (Mon,) studied this question.