Experimental chronic pulmonary hypertension in piglets significantly reduced right ventricular reserve, demonstrated by a lower dobutamine-induced change in stroke volume index (20% vs 47%; p<0.01).
Does experimental pulmonary hypertension alter right ventricular reserve and ventricular-arterial coupling in a piglet model?
In a piglet model of chronic pulmonary hypertension, right ventricular reserve is significantly impaired and strongly correlates with resting ventricular-arterial coupling.
Absolute Event Rate: 20% vs 47%
p-value: p=<0.01
Right ventricular (RV) response to exercise or pharmacological stress is not well documented in pulmonary hypertension (PH). We investigated the relationship between RV reserve and ventricular-arterial coupling. Surgical ligation of the left pulmonary artery was performed in 13 Large White piglets (PH group), thereafter weekly embolisations of the right lower lobe were performed for 5 weeks. A control group of six piglets underwent sham procedures. Right heart catheterisation and echocardiography were performed at week 6. Pressure-volume loops were recorded before and after dobutamine infusion. Induction of experimental PH resulted in a higher mean ± sd pulmonary artery pressure (34 ± 9 versus 14 ± 2 mmHg; p<0.01) and in a lower ventricular-arterial coupling efficiency (0.66 ± 0.18 versus 1.24 ± 0.17; p<0.01) compared with controls at 6 weeks. Dobutamine-induced relative changes in RV stroke volume index (SVI) and end-systolic elastance were lower in the PH group (mean ± SD 47 ± 5% versus 20 ± 5%, p<0.01, and 81 ± 37% versus 32 ± 14%, p<0.01, respectively). Change in SVI was strongly associated with resting ventricular-arterial coupling (R(2)=0.74; p<0.01). RV reserve was associated with ventricular-arterial coupling in a porcine model of chronic pressure overload.
Guihaire et al. (Wed,) conducted a other in Chronic pulmonary hypertension (n=19). Experimental induction of pulmonary hypertension vs. Sham procedures was evaluated on Dobutamine-induced relative change in RV stroke volume index (p=<0.01). Experimental chronic pulmonary hypertension in piglets significantly reduced right ventricular reserve, demonstrated by a lower dobutamine-induced change in stroke volume index (20% vs 47%; p<0.01).