Microscopic examination of an autopsy case of LHIS revealed proliferation of mature fat, brown fat, and cardiac muscle cells, suggesting it is a hamartomatous rather than hypertrophic lesion.
Case Report (n=1)
Pathological findings of a cardiac interatrial septum lesion suggest it is a hamartoma rather than hypertrophy, prompting a proposed nomenclature change.
An autopsy case of "lipomatous hypertrophy of the cardiac interatrial septum" (LHIS) combined with marked stenosis and calcification of the aortic and mitral valves due to fibrous valvular endocarditis, malignant lymphoma, and mucin-producing cancer of the pancreas is reported. LHIS and mucin-producing cancer of the pancreas were incidental findings at autopsy. Microscopically, the LHIS in this case consisted of proliferation of mature fat cells, brown fat cells and cardiac muscle cells. Since these three cell types are normal structural components of the interatrial septum, it was considered that the LHIS was a hamartomatous rather than hypertrophic lesion, of the cardiac atrial septum. Accordingly it was concluded that the term "lipomatous hamartoma of the cardiac atrial septum" was more appropriate for this lesion in the case presented here. As far as we know, this is the first reported case of LHIS in Japan.
Inoue et al. (Thu,) conducted a case report in Lipomatous hypertrophy of the cardiac interatrial septum (LHIS) (n=1). Lipomatous hypertrophy of the cardiac interatrial septum (LHIS) was evaluated on Histological findings at autopsy. Microscopic examination of an autopsy case of LHIS revealed proliferation of mature fat, brown fat, and cardiac muscle cells, suggesting it is a hamartomatous rather than hypertrophic lesion.