What question did this study set out to answer?

This research aims to investigate the role of chronic intermittent hypoxia in activating angiopoietin-like 4 and its contribution to atherosclerosis.

January 18, 2013Open Access

View Full Paper

Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4

LDLuciano F. DragerPreventive Cardiology QYQiaoling YaoXinjiang Medical University KHKaren HernandezSouth Texas Accelerated Research Therapeutics

Key Points

This research aims to investigate the role of chronic intermittent hypoxia in activating angiopoietin-like 4 and its contribution to atherosclerosis.
Examined the increase in adipose Angptl4 mediated by HIF-1

Structured PICO

Population

Patients with sleep apnea (context for chronic intermittent hypoxia)

Intervention

Chronic intermittent hypoxia

Outcome

Atherosclerosis

Identifies a potential mechanism (HIF-1/Angptl4 pathway) by which chronic intermittent hypoxia in sleep apnea contributes to atherosclerosis.

Abstract

HIF-1-mediated increase in adipose Angptl4 and the ensuing lipoprotein lipase inactivation may contribute to atherosclerosis in patients with sleep apnea.

Ask AI

Helpful

Bookmark

View Full Paper

Ask AI

Helpful

Bookmark

View Full Paper

Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4

Key Points

Structured PICO

Abstract

Cite This Study

Also Consider

Also Consider