Abnormal high-sensitivity cardiac troponin T (>0.014 ng/ml) was associated with increased cardiovascular events in hypertrophic cardiomyopathy compared to normal levels (32% vs 7%; HR 5.05, p<0.001).
Cohort (n=183)
Does an abnormal high-sensitivity cardiac troponin T (hs-cTnT) level predict cardiovascular events in patients with hypertrophic cardiomyopathy?
In patients with hypertrophic cardiomyopathy, abnormal hs-cTnT levels independently predict adverse cardiovascular outcomes, with risk increasing proportionally to hs-cTnT elevation.
Effect estimate: HR 5.05
Absolute Event Rate: 32% vs 7%
p-value: p=<0.001
OBJECTIVES This study investigated the significance of the serum high-sensitivity cardiac troponin T (hs-cTnT) marker for prediction of adverse events in hypertrophic cardiomyopathy (HCM). BACKGROUND Although serum cardiac troponins as sensitive and specific markers of myocardial injury have become well-established diagnostic and prognostic markers in acute coronary syndrome, the usefulness of hs-cTnT for prediction of cardiovascular events in patients with HCM is unclear. METHODS We performed clinical evaluation, including measurements of hs-cTnT in 183 consecutive patients with HCM. RESULTS Of 183 HCM patients, 99 (54%) showed abnormal hs-cTnT values (>0.014 ng/ml). During a mean follow-up of 4.1 ± 2.0 years, 32 (32%) of the 99 patients in the abnormal hs-cTnT group, but only 6 (7%) of 84 patients with normal hs-cTnT values, experienced cardiovascular events: cardiovascular deaths, unplanned heart failure admissions, sustained ventricular tachycardia, embolic events, and progression to New York Heart Association functional class III or IV status (hazard ratio HR: 5.05, p < 0.001). Abnormal hs-cTnT value remained an independent predictor of these cardiovascular events after multivariate analysis (HR: 3.23, p = 0.012). Furthermore, in the abnormal hs-cTnT group, overall risk increased with an increase in hs-cTnT value (HR: 1.89/hs-cTnT 1 SD increase in the logarithmic scale, 95% confidence interval: 1.13 to 3.15; p = 0.015 SD: 0.59). CONCLUSIONS In patients with HCM, an abnormal serum concentration of hs-cTnT is an independent predictor of adverse outcome, and a higher degree of abnormality in hs-cTnT value is associated with a greater risk of cardiovascular events.
Kubo et al. (Tue,) conducted a cohort in Hypertrophic cardiomyopathy (n=183). Abnormal high-sensitivity cardiac troponin T (>0.014 ng/ml) vs. Normal high-sensitivity cardiac troponin T was evaluated on Cardiovascular events (cardiovascular deaths, unplanned heart failure admissions, sustained ventricular tachycardia, embolic events, and progression to NYHA class III or IV status) (HR 5.05, p=<0.001). Abnormal high-sensitivity cardiac troponin T (>0.014 ng/ml) was associated with increased cardiovascular events in hypertrophic cardiomyopathy compared to normal levels (32% vs 7%; HR 5.05, p<0.001).