Quantifiable Internal REFERENCE Standards for Immunohistochemistry

Department of Pathology and Laboratory Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA Reprints: Clive R. Taylor MD, Department of Pathology and Laboratory Medicine, Keck School of Medicine of the University of the Southern California, HMR 204, 2011, Zonal Avenue, Los Angeles, CA 90033 (e-mail: email protected). Hypothesis: "Absent uniform sample preparation for formalin paraffin tissues, and absent available tissue reference standards, it is proposed that selected defined analytes (proteins) present intrinsically within tissues may be employed as quantifiable internal reference standards, against which sample quality can be directly assessed and key analytes directly quantified by immunohistochemistry."