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A NiFeSe-hydrogenase able to produce H(2) in the presence of O(2) forms the basis of a hybrid enzyme-TiO(2) nanoparticle system with a co-attached synthetic Ru photosensitiser for visible-light driven H(2) production at room temperature from neutral water under non-strictly anaerobic conditions on the bench.
Reisner et al. (2008) studied this question.