January 1, 2008Chemical Communications77 citations

2-(Aminoaryl)alkanone O-phenyl oximes: versatile reagents for syntheses of quinazolines

FPFernando Portela‐Cubillo JSJ. Scott JWJohn C. Walton

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Abstract

Microwave irradiations of 2-(aminoaryl)alkanone O-phenyl oximes and carbonyl compounds generate iminyl radicals in company with imines; iminyl on imine ring closure yields dihydroquinazolines or quinazolines when ZnCl2 is included in the mixture.

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Portela‐Cubillo et al. (2008) studied this question.

synapsesocial.com/papers/6a7e599f196d67da7483e446 https://doi.org/https://doi.org/10.1039/b803630f

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1Homolytic acylation of protonated pyridines and pyrazines with .alpha.-keto acids: the problem of monoacylation1991 · 213 citations
2A new and synthetically useful source of iminyl radicals.1991 · 107 citations
3Thermolyses of O-Phenyl Oxime Ethers. A New Source of Iminyl Radicals and a New Source of Aryloxyl Radicals2004 · 71 citations
4Rational design of quinazoline-based irreversible inhibitors of human erythrocyte purine nucleoside phosphorylase1991 · 80 citations
5Kinetics of the formation of imines from acetone and primary amines. Evidence for internal acid-catalyzed dehydration of certain intermediate carbinolamines1973 · 47 citations

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