What does this research mean for the field?

The structural gene for the major antigen (VP1) of foot and mouth disease virus (FMDV) strain O1K comprises 639 nucleotides encoding 213 amino acids, and lacks flanking start and stop codons, which is consistent with its biosynthesis via post-translational processing of a polyprotein precursor. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

January 1, 1981Open Access

Nucleotide sequence and corresponding amino acid sequence of the gene for the major antigen of foot and mouth disease virus

CKChristina KurzUniversity of Hohenheim SFSonja ForssFinnish Environment Institute HKHans KüpperTân Tạo University

Structured PICO

Population

Foot and mouth disease virus (FMDV) strain O1K genome (cloned cDNA)

Intervention

Nucleotide sequencing of a 1160 nucleotide segment

Outcome

Nucleotide and corresponding amino acid sequence of the viral capsid protein VP1

The study determined the nucleotide and amino acid sequence of the major antigenic polypeptide VP1 of FMDV, revealing its biosynthesis via post-translational processing.

Abstract

A segment of 1160 nucleotides of the FMDV genome has been sequenced using three overlapping fragments of cloned cDNA from FMDV strain O1K. This sequence contains the coding sequence for the viral capsid protein VP1 as shown by its homology to known and newly determined amino acid sequences from this man antigenic polypeptide of the FMDV virion. The structural gene for VP1 comprises 639 nucleotides which specify a sequence of 213 amino acids for the VP1 protein. The coding sequence is not flanked by start and stop codons which is consistent with the mode of biosynthesis of VP1 by post-translational processing of a polyprotein precursor.

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