Does high frequency or dose of NSAIDs or acetaminophen increase the risk of major cardiovascular events compared to moderate use?
High frequency or dose of NSAIDs or acetaminophen is associated with an increased risk of major cardiovascular events, whereas moderate use does not confer substantial risk.
Use of NSAIDs or acetaminophen at high frequency or dose is associated with a significantly increased risk for major cardiovascular events, although more moderate use did not confer substantial risk.
Chan et al. (Tue,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: