Does 6 months of treatment with losartan or enalapril improve exercise capacity and skeletal muscle biochemical changes in patients with heart failure?
Patients with heart failure
Losartan for 6 months
Enalapril for 6 months
Exercise capacity (EC) and myosin heavy chain (MHC) isoform shifts in leg skeletal musclesurrogate
Losartan and enalapril similarly improve exercise capacity in heart failure, potentially driven by favorable biochemical shifts in skeletal muscle myosin heavy chains.
Six months' treatment with L and with E produces an improvement in EC of similar magnitude. These changes are accompanied by a reshift of MHCs of leg skeletal muscle toward the slow, more fatigue-resistant isoforms. Magnitude of MHC1 changes correlates with the net peak V(O2) gain, which suggests that improved EC may be caused by favorable biochemical changes occurring in the skeletal muscle.
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Giorgio Vescovo
Heart Failure & Transplant
Luciano Dalla Libera
University of Padua
Francesco Serafini
Ospedale dell' Angelo
Circulation
University of Padua
Venice International University
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Vescovo et al. (Tue,) studied this question.
synapsesocial.com/papers/69d7b713dcc7b92a43f30cdc — DOI: https://doi.org/10.1161/01.cir.98.17.1742