Phase contrast ultrashort TE (PC-UTE) demonstrated <5% flow error at high flow rates (1080 mL/s) in a phantom model, outperforming conventional sequences which had >5% error at 400 mL/s.
Does a phase contrast ultrashort TE (PC-UTE) MRI sequence improve the accuracy of peak velocity measurements in high-velocity turbulent stenotic jets compared to conventional phase contrast MRI?
The PC-UTE MRI sequence significantly reduces intravoxel dephasing signal loss, providing more reliable peak velocity and flow measurements in high-velocity stenotic jets compared to conventional methods.
Accurate measurement of peak velocity is critical to the assessment of patients with stenotic valvular disease. Conventional phase contrast (PC) methods for imaging high-velocity jets in aortic stenosis are susceptible to intravoxel dephasing signal loss, which can result in unreliable measurements. The most effective method for reducing intravoxel dephasing is to shorten the echo time (TE); however, the amount that TE can be shortened in conventional sequences is limited. A new sequence incorporating velocity-dependent slice excitation and ultrashort TE (UTE) centric radial readout trajectories is proposed that reduces TE from 2.85 to 0.65 ms. In a high-velocity stenotic jet phantom, a conventional sequence had >5% flow error at a flow rate of only 400 mL/s (velocity >358 cm/s), whereas the PC-UTE showed excellent agreement (<5% error) at much higher flow rates (1080 mL/s, 965 cm/s). In vivo feasibility studies demonstrated that by measuring velocity over a shorter time the PC-UTE approach is more robust to intravoxel dephasing signal loss. It also has less inherent higher-order motion encoding. This sequence therefore demonstrates potential as a more robust method for measuring peak velocity and flow in high-velocity turbulent stenotic jets.
O’Brien et al. (Mon,) conducted a other in Stenotic valvular disease. Phase contrast ultrashort TE (PC-UTE) sequence vs. Conventional phase contrast (PC) sequence was evaluated on Flow error in high-velocity stenotic jet phantom. Phase contrast ultrashort TE (PC-UTE) demonstrated <5% flow error at high flow rates (1080 mL/s) in a phantom model, outperforming conventional sequences which had >5% error at 400 mL/s.
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