Combined therapy with valsartan and captopril reduced pulse wave velocity and augmentation index more than monotherapy in hypertensive patients (P < .05).
RCT (n=12)
cross-over
p-value: p=<.05
We measured the effects of angiotensin II blockade on arterial stiffness, augmentation index (AI%), pulse wave velocity (PWV), and blood pressure (BP) in 12 hypertensive patients (mean 49 +/- 11 years) in a 4-week, randomized, cross-over study comparing valsartan 160 mg/day with captopril 100 mg/day, with a 2-week washout period. Subsequently both therapies were combined. Reductions in PWV and AI% remained significant when corrected for BP. Combined therapy reduced PWV and AI% (P < .05) more than monotherapy, even when corrected for BP. The study shows that angiotensin receptor antagonists reduce arterial stiffness in hypertension comparable with and possibly additive to angiotensin converting enzyme inhibition.
Mahmud et al. (Mon,) conducted a rct in hypertension (n=12). Valsartan vs. Captopril 100 mg/day was evaluated on arterial stiffness, augmentation index (AI%), pulse wave velocity (PWV), and blood pressure (BP) (p=<.05). Combined therapy with valsartan and captopril reduced pulse wave velocity and augmentation index more than monotherapy in hypertensive patients (P < .05).