Statin therapy for primary prevention in adults aged 75 to 94 years is projected to prevent 105,000 incident MIs and 68,000 CHD deaths over 10 years at $25,200 per disability-adjusted life-year.
Does statin therapy for primary prevention reduce myocardial infarction and coronary heart disease death in U.S. adults aged 75 to 94 years?
Statins are projected to be cost-effective for primary prevention in adults aged 75 to 94 years, but cardiovascular benefits could be offset by small increases in geriatric-specific adverse effects.
BACKGROUND: Evidence to guide primary prevention in adults aged 75 years or older is limited. OBJECTIVE: To project the population impact and cost-effectiveness of statin therapy in adults aged 75 years or older. DESIGN: Forecasting study using the Cardiovascular Disease Policy Model, a Markov model. DATA SOURCES: Trial, cohort, and nationally representative data sources. TARGET POPULATION: U. S. adults aged 75 to 94 years. TIME HORIZON: 10 years. PERSPECTIVE: Health care system. INTERVENTION: Statins for primary prevention based on low-density lipoprotein cholesterol threshold of 4. 91 mmol/L (190 mg/dL), 4. 14 mmol/L (160 mg/dL), or 3. 36 mmol/L (130 mg/dL) ; presence of diabetes; or 10-year risk score of at least 7. 5%. OUTCOME MEASURES: Myocardial infarction (MI), coronary heart disease (CHD) death, disability-adjusted life-years, and costs. RESULTS OF BASE-CASE ANALYSIS: All adults aged 75 years or older in the National Health and Nutrition Examination Survey have a 10-year risk score greater than 7. 5%. If statins had no effect on functional limitation or cognitive impairment, all primary prevention strategies would prevent MIs and CHD deaths and be cost-effective. Treatment of all adults aged 75 to 94 years would result in 8 million additional users and prevent 105 000 (4. 3%) incident MIs and 68 000 (2. 3%) CHD deaths at an incremental cost per disability-adjusted life-year of 25 200. RESULTS OF SENSITIVITY ANALYSIS: An increased relative risk for functional limitation or mild cognitive impairment of 1. 10 to 1. 29 could offset the cardiovascular benefits. LIMITATION: Limited trial evidence targeting primary prevention in adults aged 75 years or older. CONCLUSION: At effectiveness similar to that in trials, statins are projected to be cost-effective for primary prevention; however, even a small increase in geriatric-specific adverse effects could offset the cardiovascular benefit. Improved data on the potential benefits and harms of statins are needed to inform decision making. PRIMARY FUNDING SOURCE: American Heart Association Western States Affiliate, National Institute on Aging, and the National Institute for Diabetes on Digestive and Kidney Diseases.
Odden et al. (Mon,) conducted a other in Primary prevention of cardiovascular disease. Statins was evaluated on Myocardial infarction (MI), coronary heart disease (CHD) death, disability-adjusted life-years, and costs. Statin therapy for primary prevention in adults aged 75 to 94 years is projected to prevent 105,000 incident MIs and 68,000 CHD deaths over 10 years at $25,200 per disability-adjusted life-year.