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INTRODUCTION Atrioventricular rhythm has been investigated in the experimental animal by a large number of observers. Among these are Lewis,1Zahn,2Williams and James,3Ganter and Zahn,4Meakins,5Rothberger and Winterberg,6Eyster and Meek,7and others. It has usually been produced experimentally by slowing the rate at which the impulses are sent out from the sino-auricular node or by preventing the spread of such impulses to other parts of the heart. The following methods have been employed for this purpose: (1) cooling the sinus node with an ice pencil or by means of the ethyl chlorid spray, (2) crushing or excising the sinus node, or (3) isolating the sinus node by making cuts about it. Atrioventricular rhythm has also been produced by stimulation of the right vagus1,7and by stimulation of the left accelerator.6We shall not discuss these observations
Frank N. Wilson (1915) studied this question.