Does dobutamine improve RV-PA coupling and cardiac output better than norepinephrine in pressure load-induced right ventricular failure?
Models of pressure load-induced right ventricular failure
Dobutamine
Norepinephrine
RV-PA coupling and cardiac outputsurrogate
Dobutamine is superior to norepinephrine in restoring RV-PA coupling and cardiac output in pressure load-induced right ventricular failure due to its stronger inotropic effect.
A transient increase in PA pressure persistently worsens PA hemodynamics, RV contractility, RV-PA coupling, and cardiac output. Dobutamine restores RV-PA coupling and cardiac output better than norepinephrine because of its more pronounced inotropic effect.
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François Kerbaul
Agence de la Biomédecine
Benoı̂t Rondelet
CHU Dinant Godinne UCL Namur
Sophie Motte
Université Libre de Bruxelles
Critical Care Medicine
Erasmus Hospital
Pulmonary Hypertension Association
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Kerbaul et al. (Thu,) studied this question.
synapsesocial.com/papers/69de4fabbf539e22705584f2 — DOI: https://doi.org/10.1097/01.ccm.0000120052.77953.07
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