Angiotensin-(1-7) is an active component of the renin-angiotensin system that stimulates prostaglandin release and possesses distinct biological functions from angiotensin II.
Research done in our laboratory has uncovered novel pathways and enzymes of the circulating and tissue renin angiotensin system. These findings followed the discovery that angiotensin-(1-7) has cellular functions different from those established for angiotensin II. Although Ang-(1-7) is not an agonist in terms of stimulating thirst or promoting aldosterone release, the heptapeptide causes neuronal excitation and vasopressin release to a degree similar to that found with angiotensin II. Furthermore, angiotensin-(1-7) stimulates the production of prostanoids by a receptor-mediated event that causes no associated rise in intracellular Ca2+. These actions of angiotensin-(1-7) illustrate the heterogenous role of angiotensin peptides as modulators of a wide range of regulatory functions in mammals. (Hypertens Res 1992; 15: 61-66)
Carlos M. Ferrario (Wed,) conducted a review in Hypertension. Angiotensin-(1-7) was evaluated. Angiotensin-(1-7) is an active component of the renin-angiotensin system that stimulates prostaglandin release and possesses distinct biological functions from angiotensin II.
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