Identifying Genes Regulated in a Myc-dependent Manner

Introduction: Cancer is a very important disease especially in older dogs and cats, affecting all breeds with high levels of mortality. In addition, the study of cancer in domestic animals allows progress in the knowledge of human cancer, because they have similarities in several aspects. The most important are related to the clinical part, drug resistance and risk factors for its development. This will expand knowledge in cancer biology, improve palliative treatments and improve the effectiveness of healing attempts. To achieve this, those that resemble the phenotype and molecular aspects should be used, but additionally be identical in the growth pattern, location and immune status of the individual. In this sense it is important both the emulation of genetic alterations, clinical characteristics and variations of the disease due to the biological diversity of cancer. Aims: To analyze the participation of the C-MYC oncogene during cancer, and of the genes P53, MDR-1 and Ki-67 as factors for the development of human cancer and its similarities with Canine Transmissible Venereal Tumor (TVTc).Methods: Theoretical review of 52 bibliographic sources of the search engines Pubmed, Scopus and Google scholar was carried out. Results: Mammalian tumors are the result of alterations in cell proliferation and differentiation genes, inhibition of tumor suppressors, repair gene failures, apoptosis and methylation mechanisms. The protooncogen C-MYC, promotes cell growth and immediate early response, but its expression is well controlled by a series of regulatory mechanisms. It is expressed in different tissues, altering cell differentiation and immortalization and expressing itself in those of greater proliferation. In addition, it is the target of estrogenic action in hormonal receptors due to sensitivity to these hormones during the cell cycle. There are molecular aspects of the C-MYC gene that indicate how it acts during Canine Transmissible Venereal Tumor (TVTc). In the DNA of mammals there are the LINEs that are inserted into the C-MYC gene, causing normal cells to become neoplastic. Canine Transmissible Venereal Tumor (TVTc) is a contagious neoplasm of dogs with two forms, genital and extra genital. The susceptible individual differs from the immune one by its inherent ability to resist contagion, so it is necessary to understand how the immune system is acting and its impact on the final outcome of patients with TVTc. In order for a tumor to become transmissible, cells must undergo adaptive processes to Vol 13 No.2, julio -diciembre de 2019 Universidad de Caldas 82