Strain-Encoded MR during dobutamine stress testing yielded significantly higher sensitivity for detecting coronary artery disease compared to cine imaging (89% vs 70%, P<0.01).
Observational (n=65)
Absolute Event Rate: 89% vs 70%
p-value: p=<0.01
PURPOSE: To investigate regional strain response during high-dose dobutamine stress cardiac magnetic resonance imaging (DS-CMR) using myocardial tagging and Strain-Encoded MR (SENC). MATERIALS AND METHODS: Stress induced ischemia was assessed by wall motion analysis, by tagged CMR and by SENC in 65 patients with suspected or known CAD who underwent DS-CMR in a clinical 1.5 Tesla scanner. Coronary angiography deemed as the standard reference for the presence or absence of CAD (> or =50% diameter stenosis) in all patients. RESULTS: SENC and conventional tagging detected abnormal strain response in six and five additional patients, respectively, who were missed by cine images and proved to have CAD by angiography (P < 0.05 for SENC versus cine, P = 0.06 for tagging versus cine and p = NS for SENC versus tagging). On a per-vessel level, wall motion analysis on cine images showed high specificity (95%) but moderate sensitivity (70%) for the detection of CAD. Tagging and SENC yielded significantly higher sensitivity of 81% and 89%, respectively (P < 0.05 for tagging and P < 0.01 for SENC versus wall motion analysis, and p = NS for SENC versus tagging), while specificity was equally high (96% and 94%, respectively, P = NS for all). CONCLUSION: Both the direct color-coded visualization of strain on CMR images and the generation of additional visual markers within the myocardium with tagged CMR represent useful adjuncts for DS-CMR, which may provide incremental value for the detection of CAD in humans. J. Magn. Reson.
Korosoglou et al. (Wed,) conducted a observational in Suspected or known coronary artery disease (n=65). Strain-Encoded MR (SENC) and myocardial tagging vs. Cine imaging (wall motion analysis) was evaluated on Sensitivity for detection of coronary artery disease (≥50% diameter stenosis) on a per-vessel level (p=<0.01). Strain-Encoded MR during dobutamine stress testing yielded significantly higher sensitivity for detecting coronary artery disease compared to cine imaging (89% vs 70%, P<0.01).