Oral alpha-tocopherol supplementation (1600 i.u. daily) for 8 weeks did not improve vasodilation to nitroprusside, acetylcholine, or bradykinin in patients with Type 2 diabetes (all P>0.1).
RCT (n=69)
Double-blind
p-value: p=>0.1
AIMS: Vascular endothelial dysfunction, an early marker of atherosclerosis, has been demonstrated in Type 2 diabetes mellitus (DM). Vitamin E preserves endothelial function in animal models of diabetes and reduces cardiovascular risk. We examined endothelial function and the effect of vitamin E supplements in uncomplicated Type 2 DM. METHODS: Forty-eight subjects with Type 2 DM and 21 controls had endothelial function assessed using forearm venous occlusion plethysmography with endothelium-independent (sodium nitroprusside) and dependent (acetylcholine, bradykinin) vasodilators. Those with diabetes received 1600 i.u. daily oral alpha-tocopherol or placebo, double-blind for 8 weeks, and had endothelial function reassessed. RESULTS: The diabetic group had higher HbA1c (6.9+/-1.4 vs 4.8+/-0.6%; P0.1). Alpha-tocopherol did not affect vasodilation to nitroprusside (P>0.1), acetylcholine (P>0.1) or bradykinin (P>0.1). CONCLUSIONS: There may be receptor-specific endothelial dysfunction in subjects with uncomplicated Type 2 DM. This is not improved by treatment with alpha-tocopherol.
Gazis et al. (Thu,) conducted a rct in Type 2 diabetes mellitus (n=69). Oral alpha-tocopherol vs. Placebo was evaluated on Vasodilation to sodium nitroprusside, acetylcholine, and bradykinin (p=>0.1). Oral alpha-tocopherol supplementation (1600 i.u. daily) for 8 weeks did not improve vasodilation to nitroprusside, acetylcholine, or bradykinin in patients with Type 2 diabetes (all P>0.1).