Paraneoplastic retinopathy with multiple detachments of the neurosensory retina and autoantibodies against interphotoreceptor retinoid binding protein (IRBP) in cutaneous melanoma

A 74 year-old Caucasian man developed gradual bilateral visual loss after diagnosis of metastatic cutaneous melanoma. Fundus exam revealed multiple serous detachments of the neurosensory retina in both eyes. Electroretinography was normal. Serologic testing showed autoantibodies to interphotoreceptor retinal binding protein (IPBP). This represents an unusual variant of MAR (melanoma associated retinopathy) syndrome.