Explanted silicone rubber valve prostheses (n=14) contained 0 phospholipids and 0 proteins, widely varying lipid contents, and residual uncured silicone polymers in all 14 valves.
Observational (n=14)
Explanted silicone rubber valve prostheses absorb various lipids but not phospholipids or proteins, and contain residual uncured silicone polymers that may interact with lipids.
Fourteen prosthetic valves were obtained from human recipients at autopsy or valve replacement surgery. The silicone rubber poppets were extracted with lipid solvent and examined by thin-layer chromatography, infrared absorption spectroscopy, and phosphorus analysis. The significant findings were: (1) No phospholipid was present in any of the valves; neither was there any protein. (2) The relative content of cholesterol, cholesteryl ester, fatty acid, and triglyceride varied widely. (3) Residual uncured silicone polymers were found in all valves; in one patient these appeared to combine with lipid and form a component with unusual chromatographic behavior.
Chin et al. (Sat,) conducted a observational in Silicone rubber valve prostheses (n=14). Silicone rubber valve prostheses was evaluated on Lipid, protein, and silicone polymer content. Explanted silicone rubber valve prostheses (n=14) contained 0 phospholipids and 0 proteins, widely varying lipid contents, and residual uncured silicone polymers in all 14 valves.
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