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Aldosterone does not exert a direct effect on collagen synthesis in rat cardiac fibroblasts grown in culture. The increased cardiac collagen observed in vivo in aldosterone treated, salt loaded rats may thus represent secondary effects of aldosterone in this model.
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Fullerton et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69af0aefe03f6d79082a8c74 — DOI: https://doi.org/10.1093/cvr/28.12.1863
M Fullerton
J. W. Funder
Cardiovascular Research
Baker Heart and Diabetes Institute
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