Higher degrees of myocardial inflammation (27.8 vs 11.1 cells/mm2) were significantly associated with early mortality from cardiac insufficiency in patients undergoing partial left ventriculectomy.
Observational (n=27)
Does the degree of myocardial inflammation affect early survival in patients with idiopathic dilated cardiomyopathy undergoing partial left ventriculectomy?
In patients with idiopathic dilated cardiomyopathy undergoing partial left ventriculectomy, a higher degree of myocardial inflammation is significantly associated with early postoperative cardiogenic mortality.
Absolute Event Rate: 27.8% vs 11.1%
Partial left ventriculectomy (PLV) can be used to treat refractory congestive heart failure caused by dilated cardiomyopathy (DCM). In order to understand the relationship between the underlying myocardial injury and early clinical outcomes after PLV, histopathologic, immunohistochemical and virologic studies of the resected myocardium were performed. The posterolateral left ventricular walls from 27 patients with idiopathic DCM were examined. Cardiomyocyte diameter, degree of myocardial fibrosis, degree of cardiomyocyte degeneration, and degree of inflammatory cell infiltration were compared with mortality rates. Polymerase chain reaction was performed to detect enterovirus genome in the myocardium. Some patients had inflammatory cell infiltrates with focal accumulations of lymphocytes and macrophages, including both cytotoxic/suppressor T-cells and helper/inducer T-cells. The number of inflammatory cells (activated lymphocytes plus macrophages/mm2) was significantly greater in patients who died of cardiac insufficiency after surgery (27.8 +/- 5.7; n = 7) than in the survivors (11.1 +/- 2.5; n = 15). There was no significant difference in the degree of myocardial fibrosis, cardiomyocyte diameter or degree of cardiomyocyte degeneration between the 2 groups. Enterovirus genome was detected in the myocardium of 9 (38%) of 24 patients examined and 5 of these enterovirus-positive hearts had severe inflammatory cell infiltrates (37.9 +/- 2.5/mm2). Early survival in patients undergoing PLV for DCM is significantly affected by the degree of myocardial inflammation, so patients with more severe or ongoing inflammation may have poor clinical outcomes. Chronic myocarditis may play an important role in the etiology and pathophysiology of idiopathic DCM.
Kanzaki et al. (Mon,) conducted a observational in Idiopathic dilated cardiomyopathy (n=27). Partial left ventriculectomy vs. Survivors vs. non-survivors was evaluated on Number of inflammatory cells (activated lymphocytes plus macrophages/mm2) in patients who died of cardiac insufficiency vs survivors. Higher degrees of myocardial inflammation (27.8 vs 11.1 cells/mm2) were significantly associated with early mortality from cardiac insufficiency in patients undergoing partial left ventriculectomy.