A Serious Complication Following Medical-Grade Silicone Injection of the Face

A serious complication following MDX4-4011 Dow-Corning silicone for injection to the face is reported. The patient developed inflammatory lesions 11 years after her last silicone injection for what was felt to be Weber-Christian disease. The patient also had a diagnosis of rheumatoid arthritis and a questionable history of mycoplasm infection. She eventually required excision of the right facial area with flap reconstruction. There is at least one other investigator who has had inflammatory complications following silicone injection to a patient with Weber-Christian disease. For these reasons, caution in using liquid silicone in patients who might have Weber-Christian disease is recommended.