What is the clinical evidence from this study?

Study design: Case Report. Population: Angiosarcoma (n=1). Intervention: Retained metal grenade fragment. Primary outcome: Development of angiosarcoma.

May 1, 1983Journal of Clinical Pathology42 citationsOpen Access

Angiosarcoma developing around a foreign body.

JHJohn Hayman HHH. Huygens

Key Result

An 86-year-old man developed an angiosarcoma around a retained metal grenade fragment 65 years after sustaining a war wound.

Study Design

Type

Case Report (n=1)

Multicenter

PICO

Population

An 86-year-old male World War I veteran who developed an angiosarcoma at the site of a retained metal grenade fragment 65 years after injury.

Exposure / Comparator

Retained metal grenade fragment

Primary Outcome

Development of angiosarcoma

Limitations

Exact relationship of tumor to foreign body could not be definitively determined in the initial biopsy
Single case report

Abstract

An 86-year-old World War I veteran developed an angiosarcoma at the site of a war wound. The tumour developed in relation to one of several metal grenade fragments. The tumour cells have been shown to contain blood coagulation factor VIII antigen and have features of endothelial cells on electron microscopy. The patient is claimed to be the last soldier dying of wounds sustained during that war, and to have the longest disease-free interval between injury and the onset of complications.

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