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The literature supports the use of hypofractionated radiotherapy or temozolomide monotherapy in the treatment of elderly patients with GBM. In patients with MGMT promoter methylation, temozolomide monotherapy may have greater benefit than radiotherapy.
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Oren Zarnett
University of British Columbia
Arjun Sahgal
Sunnybrook Health Science Centre
Jessica Gosio
Mount Sinai Hospital
JAMA Neurology
University of Toronto
University of California, San Francisco
Neurological Surgery
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Zarnett et al. (Mon,) studied this question.
synapsesocial.com/papers/69d85136d2f7327e70ae2f67 — DOI: https://doi.org/10.1001/jamaneurol.2014.3739