Low heart rate recovery and metabolic equivalents increased cardiovascular death risk versus high HRR/METs in women (HR 8.51, 95% CI 3.65-19.84) and men (HR 3.53, 95% CI 2.03-6.15).
Cohort (n=6,126)
Effect estimate: HR 8.51 (women), HR 3.53 (men) (95% CI 3.65-19.84 (women), 2.03-6.15 (men))
p-value: p=<0.001
BACKGROUND: National Cholesterol Education Program Adult Treatment Panel III (ATP III) guidelines recommend the use of Framingham risk scores (FRS) for cardiovascular assessment of asymptomatic individuals. We hypothesized that risk prediction could be improved with 2 non-ECG exercise test measures, exercise capacity (metabolic equivalents, or METs) and heart rate recovery (HRR). METHODS AND RESULTS: An asymptomatic cohort with baseline treadmill tests (n=6126; 46% women, FRS 0.5% annual CVD mortality) in half of women with FRS 6% to 9% and 10% to 19% and just under half of men with FRS 10% to 19%. Low HRR/low METs was also associated with an increased relative risk of CVD death in individuals with low-risk FRS (FRS <6% in women and <10% in men), but absolute CVD mortality rates were low in this subgroup. CONCLUSIONS: Exercise testing may be a useful adjunct for clinical risk assessment in asymptomatic women with FRS 6% to 19% and men with FRS 10% to 19%.
Mora et al. (Wed,) conducted a cohort in Asymptomatic individuals (n=6,126). Low heart rate recovery (HRR) and low metabolic equivalents (METs) vs. High HRR and high METs was evaluated on Cardiovascular disease (CVD) death (HR 8.51 (women), HR 3.53 (men), 95% CI 3.65-19.84 (women), 2.03-6.15 (men), p=<0.001). Low heart rate recovery and metabolic equivalents increased cardiovascular death risk versus high HRR/METs in women (HR 8.51, 95% CI 3.65-19.84) and men (HR 3.53, 95% CI 2.03-6.15).