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A variety of actin-binding proteins have been purified during the last few years from many different cell types. A group of these proteins share certain features, having similar subunit molecular weights on SDS-poly-acrylamide gels (∼100,000) and being affected by calcium in their interaction with actin. Names have been given to some of these proteins, such as actinogelin from Ehrlich ascites cells (Mimura and Asano 1978, 1979), gelsolin from macrophages (Yin and Stossel 1979, 1980), and villin from the microvilli of epithelial brush borders (Bretscher and Weber 1979). Other proteins have been referred to by cell type and apparent molecular weight, such as Dictyostelium 95K protein (Hellewell and Taylor 1979; Condeelis 1981), platelet 95K protein (Wang and Bryan 1980), and Acanthamoeba 85K protein (Pollard et al. 1980). In this analysis of calcium-sensitive, actin-binding proteins, the protein α-actinin has received relatively little attention, even though it is an actin-binding protein with a...
Burridge et al. (Fri,) studied this question.