Long-term propranolol therapy in hypertensive men decreased effective renal plasma flow by 14% and renal blood flow by 15%, without expanding plasma volume or altering body fluid composition.
Observational (n=14)
Does propranolol monotherapy affect renal function and body fluid composition in hypertensive men?
Propranolol monotherapy in hypertensive men reduces renal blood flow and plasma flow but does not significantly alter GFR, body fluid volumes, or electrolyte handling.
Fourteen hypertensive men underwent assessment of renal function and body fluid composition following short-term (three to six weeks), long-term (five to six months), and withdrawal (two weeks) of propranolol hydrochloride monotherapy for the treatment of hypertension. Results indicate that propranolol had little effect on glomerular filtration rate (less than 10% decrease); changes that did occur were directly correlated with changes in effective renal plasma flow. Propranolol therapy decreased effective renal plasma flow 14% and renal blood flow 15% during long-term therapy; decreases in renal perfusion persisted following withdrawal of therapy. Propranolol therapy was neither antidiuretic nor antinatriuretic; propranolol had no effect on urine osmolality, free water clearance, sodium clearance, or fractional sodium excretion. Furthermore, propranolol therapy did not expand plasma volume, extracellular fluid volume, or total body water. Finally, propranolol therapy had no effect on the renal handling of potassium or on serum potassium concentration.
John H. Bauer (Sun,) conducted a observational in Hypertension (n=14). Propranolol hydrochloride monotherapy was evaluated on Renal function and body fluid composition. Long-term propranolol therapy in hypertensive men decreased effective renal plasma flow by 14% and renal blood flow by 15%, without expanding plasma volume or altering body fluid composition.
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