Prophylactic therapy with mexiletine and propranolol effectively prevented ventricular fibrillation for over 3 years in a patient with idiopathic ventricular fibrillation and persistent ST elevation.
Case Report (n=1)
No
Idiopathic ventricular fibrillation (n=1)
Propranolol and mexiletine (mexiletine 300mg/day and propranolol 30mg/day)
Prevention of ventricular fibrillation
We report the case of a 42-year-old male who suffered from ventricular fibrillation (VF) without obvious QT prolongation. His electrocardiogram showed incomplete right bundle branch block (IRBBB) and persistent ST segment elevation in the right precordial leads during sinus rhythm. Cardiac catheterization revealed no overt heart disease except moderate endocardial and subendocardial fibrosis in the left ventricle. Mental stress seemed to trigger VF, and ST elevation became prominent just before VF. Propranolol and mexiletine have been effective in preventing VF for over 3 years.
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Masataka Sumiyoshi
Juntendo University Nerima Hospital
Yasuro Nakata
Aichi Medical University
Teruhiko Hisaoka
United States Golf Association
Japanese Heart Journal
Juntendo University
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Sumiyoshi et al. (Fri,) conducted a case report in Idiopathic ventricular fibrillation (n=1). Propranolol and mexiletine was evaluated on Prevention of ventricular fibrillation. Prophylactic therapy with mexiletine and propranolol effectively prevented ventricular fibrillation for over 3 years in a patient with idiopathic ventricular fibrillation and persistent ST elevation.
synapsesocial.com/papers/6a0cfa6eb31ab1d6e01e73da — DOI: https://doi.org/10.1536/ihj.34.661