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Ventilation, respiratory frequency and the alveolar gas pressures have been measured in the steady state in resting man breathing various gas mixtures. In confirmation of the results of earlier workers, the slope of the linear part of the relation between ventilation and carbon dioxide has been shown to be an inverse function of the alveolar oxygen pressure, and the form of this function is discussed. The intercept of the V-pCO2 line on the pCO2 axis is independent of P02* THE relationships in the steady state between pulmonary ventilation (V, 1./min., B.T.P.S.) and the partial pressures of alveolar carbon dioxide (pCO2) and oxygen (PO2) have been observed in two ways. The V-pCO2 relation, which over a certain range is linear, has been investigated at several constant inspired P02's Lindhard, 1911; Nielsen, 1936; Hall, 1953, and at a few constant alveolar P02'S Nielsen and Smith, 1951; Asmussen and Nielsen, 1957; Kellogg, Vaughan and Badger, 1957. The V-PO2 relation, which is not linear, has been investigated at several constant pCO2's Cormack, Cunningham and Gee, 1957. Both these approaches reveal positive inter- action between the respiratory effects of the two gases, and fail to support the contention of
Lloyd et al. (Mon,) studied this question.