Oxidative stress induced by hyperglycemia, hyperlipidemia, hypertension, and inflammation is a major risk factor for the pathogenesis of diabetic cardiomyopathy.
Oxidative stress driven by metabolic and inflammatory factors plays a central role in the microvascular pathogenesis and cellular damage of diabetic cardiomyopathy.
Diabetic cardiomyopathy as an important threat to health occurs with or without coexistence of vascular diseases. The exact mechanisms underlying the disease remain incompletely clear. Although several pathological mechanisms responsible for diabetic cardiomyopathy have been proposed, oxidative stress is widely considered as one of the major causes for the pathogenesis of the disease. Hyperglycemia-, hyperlipidemia-, hypertension- and inflammation-induced oxidative stress are major risk factors for the development of microvascular pathogenesis in the diabetic myocardium, which results in abnormal gene expression, altered signal transduction and the activation of pathways leading to programmed myocardial cell deaths. In the present article, we aim to provide an extensive review of the role of oxidative stress and anti-oxidants in diabetic cardiomyopathy based on our own works and literature information available.
Liu et al. (Tue,) conducted a review in Diabetic cardiomyopathy. Oxidative stress and anti-oxidants was evaluated. Oxidative stress induced by hyperglycemia, hyperlipidemia, hypertension, and inflammation is a major risk factor for the pathogenesis of diabetic cardiomyopathy.
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