Severe flecainide overdose in a 70-year-old man elicited profound QRS widening and ST-segment elevation typical of the Brugada sign, which resolved over 5 days without arrhythmias.
Case Report (n=1)
Does severe flecainide overdose elicit a Brugada electrocardiographic pattern in a patient without hereditary Brugada syndrome?
Severe flecainide overdose can elicit a transient Brugada electrocardiographic pattern even in patients without clinical evidence of hereditary Brugada syndrome.
In a 70-year-old man, without clinical suggestion of the hereditary form of the Brugada syndrome, severe flecainide overdose resulted in profound widening of the QRS complex and the development of ST-T abnormalities typical of the Brugada sign. Serial ECGs recorded over a 5-day period revealed a parallel pattern of dynamic intraventricular conduction defect and ST-segment elevation. Resolution of ST-segment elevation lagged behind resolution of the QRS widening by 16-20 hours. Despite the marked Brugada abnormality no arrhythmia occurred and the patient recovered without complications.
Hudson et al. (Wed,) conducted a case report in Flecainide overdose (n=1). Flecainide was evaluated on ECG changes (QRS widening and ST-segment elevation). Severe flecainide overdose in a 70-year-old man elicited profound QRS widening and ST-segment elevation typical of the Brugada sign, which resolved over 5 days without arrhythmias.